Telomere Longevity and DNA Repair

Telomere Longevity and DNA Repair

DNA needing repair may have adverse results on your telomeres!

Researchers have found that inhibiting DNA recombination at the telomeres can promote longevity, at least in yeast.

“Homologous recombination is a process used to repair double stranded breaks in DNA, thereby preventing genome instability which is believed to cause aging. The shortening of telomeres, the physical ends of eukaryotic linear chromosomes, has also implicated in aging. However, due to the resemblance of telomeres to DNA double strand breaks (DSBs), homologous recombination can not be eliminated from telomeres.

Professor Zhou Jinqiu and his group at the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, has now identified a telomere recombination regulator, the yeast KEOPS subunit Cgi121, as a novel longevity regulator. They showed that inactivation of Cgi121 inhibited telomere recombination and significantly extended the lifespan of yeast.

In the present study, Zhou and colleagues confirmed that telomere recombination accelerates aging and inhibition of homologous recombination at the telomeres restores lifespan.” – Asian Scientist